Epigenetic Induction of Definitive and Pancreatic Endoderm Cell Fate in Human Fibroblasts

Reprogramming can occur by the introduction of key transcription factors (TFs) as well as by epigenetic changes. We demonstrated that histone deacetylase inhibitor (HDACi) Trichostatin A (TSA) combined with a chromatin remodeling medium (CRM) induced expression of a number of definitive endoderm and...

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Detalles Bibliográficos
Autores principales: Sambathkumar, Rangarajan, Kalo, Eric, Van Rossom, Rob, Faas, Marijke M., de Vos, Paul, Verfaillie, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925994/
https://www.ncbi.nlm.nih.gov/pubmed/27403168
http://dx.doi.org/10.1155/2016/7654321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925994/
https://www.ncbi.nlm.nih.gov/pubmed/27403168
http://dx.doi.org/10.1155/2016/7654321

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