Enlarged colitogenic T cell population paradoxically supports colitis prevention through the B-lymphocyte-dependent peripheral generation of CD4(+)Foxp3(+) Treg cells

Intestinal inflammation can be induced by the reconstitution of T/B cell-deficient mice with low numbers of CD4(+) T lymphocytes depleted of CD25(+)Foxp3(+) regulatory T cells (Treg). Using RAG-knockout mice as recipients of either splenocytes exclusively depleted of CD25(+) cells or FACS-purified C...

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Detalles Bibliográficos
Autores principales: do Canto, Fábio Barrozo, Campos, Sylvia Maria Nicolau, Granato, Alessandra, da Silva, Rafael F., de Paiva, Luciana Souza, Nóbrega, Alberto, Bellio, Maria, Fucs, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926115/
https://www.ncbi.nlm.nih.gov/pubmed/27353032
http://dx.doi.org/10.1038/srep28573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926115/
https://www.ncbi.nlm.nih.gov/pubmed/27353032
http://dx.doi.org/10.1038/srep28573

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