Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor

Drug resistance of mutations in HIV-1 protease (PR) is the most severe challenge to the long-term efficacy of HIV-1 PR inhibitor in highly active antiretroviral therapy. To elucidate the molecular mechanism of drug resistance associated with mutations (D30N, I50V, I54M, and V82A) and inhibitor (GRL-...

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Detalles Bibliográficos
Autores principales: Hu, Guodong, Ma, Aijing, Dou, Xianghua, Zhao, Liling, Wang, Jihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926353/
https://www.ncbi.nlm.nih.gov/pubmed/27240358
http://dx.doi.org/10.3390/ijms17060819

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926353/
https://www.ncbi.nlm.nih.gov/pubmed/27240358
http://dx.doi.org/10.3390/ijms17060819

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