Finding a Potential Dipeptidyl Peptidase-4 (DPP-4) Inhibitor for Type-2 Diabetes Treatment Based on Molecular Docking, Pharmacophore Generation, and Molecular Dynamics Simulation

Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that is responsible for inactivating intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP), which stimulates a decline in blood glucose levels. The aim of this study was to explore the inhibition activity of sm...

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Detalles Bibliográficos
Autores principales: Meduru, Harika, Wang, Yeng-Tseng, Tsai, Jeffrey J. P., Chen, Yu-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926453/
https://www.ncbi.nlm.nih.gov/pubmed/27304951
http://dx.doi.org/10.3390/ijms17060920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926453/
https://www.ncbi.nlm.nih.gov/pubmed/27304951
http://dx.doi.org/10.3390/ijms17060920

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