N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability

R-spondin 1 (Rspo1) plays an essential role in stem cell biology by potentiating Wnt signaling activity. Despite the fact that Rspo1 holds therapeutic potential for a number of diseases, its biogenesis is not fully elucidated. All Rspo proteins feature two amino-terminal furin-like repeats, which ar...

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Detalles Bibliográficos
Autores principales: Chang, Chiung-Fang, Hsu, Li-Sung, Weng, Chieh-Yu, Chen, Chih-Kai, Wang, Shu-Ying, Chou, Yi-Hwa, Liu, Yan-Yu, Yuan, Zi-Xiu, Huang, Wen-Ying, Lin, Ho, Chen, Yau-Hung, Tsai, Jen-Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926470/
https://www.ncbi.nlm.nih.gov/pubmed/27314333
http://dx.doi.org/10.3390/ijms17060937

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926470/
https://www.ncbi.nlm.nih.gov/pubmed/27314333
http://dx.doi.org/10.3390/ijms17060937

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