TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation

The 18-kDa translocator protein (TSPO) is a potential mitochondrial target for drug delivery to tumors overexpressing TSPO, including brain cancers, and selective TSPO ligands have been successfully used to selectively deliver drugs into the target. Methotrexate (MTX) is an anticancer drug of choice...

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Detalles Bibliográficos
Autores principales: Laquintana, Valentino, Denora, Nunzio, Cutrignelli, Annalisa, Perrone, Mara, Iacobazzi, Rosa Maria, Annese, Cosimo, Lopalco, Antonio, Lopedota, Angela Assunta, Franco, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926499/
https://www.ncbi.nlm.nih.gov/pubmed/27322261
http://dx.doi.org/10.3390/ijms17060967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926499/
https://www.ncbi.nlm.nih.gov/pubmed/27322261
http://dx.doi.org/10.3390/ijms17060967

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