Mobilization of Intracellular Copper by Gossypol and Apogossypolone Leads to Reactive Oxygen Species-Mediated Cell Death: Putative Anticancer Mechanism

There is compelling evidence that serum, tissue and intracellular levels of copper are elevated in all types of cancer. Copper has been suggested as an important co-factor for angiogenesis. It is also a major metal ion present inside the nucleus, bound to DNA bases, particularly guanine. We have ear...

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Detalles Bibliográficos
Autores principales: Zubair, Haseeb, Azim, Shafquat, Khan, Husain Yar, Ullah, Mohammad Fahad, Wu, Daocheng, Singh, Ajay Pratap, Hadi, Sheikh Mumtaz, Ahmad, Aamir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926505/
https://www.ncbi.nlm.nih.gov/pubmed/27331811
http://dx.doi.org/10.3390/ijms17060973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926505/
https://www.ncbi.nlm.nih.gov/pubmed/27331811
http://dx.doi.org/10.3390/ijms17060973

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