Aneuploidy impairs hematopoietic stem cell fitness and is selected against in regenerating tissues in vivo

Aneuploidy, an imbalanced karyotype, is a widely observed feature of cancer cells that has long been hypothesized to promote tumorigenesis. Here we evaluate the fitness of cells with constitutional trisomy or chromosomal instability (CIN) in vivo using hematopoietic reconstitution experiments. We di...

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Detalles Bibliográficos
Autores principales: Pfau, Sarah J., Silberman, Rebecca E., Knouse, Kristin A., Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926863/
https://www.ncbi.nlm.nih.gov/pubmed/27313317
http://dx.doi.org/10.1101/gad.278820.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926863/
https://www.ncbi.nlm.nih.gov/pubmed/27313317
http://dx.doi.org/10.1101/gad.278820.116

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