Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

Aging is a risk factor for many human pathologies and is characterized by extensive metabolic changes. Using targeted high-throughput metabolite profiling in Drosophila melanogaster at different ages, we demonstrate that methionine metabolism changes strikingly during aging. Methionine generates the...

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Detalles Bibliográficos
Autores principales: Parkhitko, Andrey A., Binari, Richard, Zhang, Nannan, Asara, John M., Demontis, Fabio, Perrimon, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926864/
https://www.ncbi.nlm.nih.gov/pubmed/27313316
http://dx.doi.org/10.1101/gad.282277.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926864/
https://www.ncbi.nlm.nih.gov/pubmed/27313316
http://dx.doi.org/10.1101/gad.282277.116

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