Cargando…

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila

Aging is a risk factor for many human pathologies and is characterized by extensive metabolic changes. Using targeted high-throughput metabolite profiling in Drosophila melanogaster at different ages, we demonstrate that methionine metabolism changes strikingly during aging. Methionine generates the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Parkhitko, Andrey A., Binari, Richard, Zhang, Nannan, Asara, John M., Demontis, Fabio, Perrimon, Norbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926864/ https://www.ncbi.nlm.nih.gov/pubmed/27313316 http://dx.doi.org/10.1101/gad.282277.116

Ejemplares similares

Functional and Pathological Roles of AHCY
por: Vizán, Pedro, et al.
Publicado: (2021)

Knock-down of AHCY and depletion of adenosine induces DNA damage and cell cycle arrest
por: Belužić, Lucija, et al.
Publicado: (2018)

DNA methylation of AHCY may increase the risk of ischemic stroke
por: Zhao, Lei, et al.
Publicado: (2020)

Chromatin capture links the metabolic enzyme AHCY to stem cell proliferation
por: Aranda, Sergi, et al.
Publicado: (2019)

Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency
por: Motzek, Antje, et al.
Publicado: (2016)

The values of AHCY and CBS promoter methylation on the diagnosis of cerebral infarction in Chinese Han population
por: Li, Xiaodong, et al.
Publicado: (2020)

Prognostic Value of Serum Exosomal AHCY Expression in Hepatitis B-Induced Liver Cirrhosis
por: Tong, Ling, et al.
Publicado: (2021)

Exosomal circ‐AHCY promotes glioblastoma cell growth via Wnt/β‐catenin signaling pathway
por: Li, Yuhui, et al.
Publicado: (2023)

S‐adenosyl‐L‐homocysteine extends lifespan through methionine restriction effects
por: Ogawa, Takafumi, et al.
Publicado: (2022)

Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma
por: Chicco, Davide, et al.
Publicado: (2023)

Acquired resistance to DZNep-mediated apoptosis is associated with copy number gains of AHCY in a B-cell lymphoma model
por: Akpa, Chidimma Agatha, et al.
Publicado: (2020)

The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes
por: Yang, Yang, et al.
Publicado: (2022)

Structural insights into the reaction mechanism of S-adenosyl-L-homocysteine hydrolase
por: Kusakabe, Yoshio, et al.
Publicado: (2015)

Downregulation of the tyrosine degradation pathway extends Drosophila lifespan
por: Parkhitko, Andrey A, et al.
Publicado: (2020)

S-adenosyl-L-homocysteine hydrolase and methylation disorders: Yeast as a model system
por: Tehlivets, Oksana, et al.
Publicado: (2013)

S-Adenosyl-L-Homocysteine Hydrolase Inhibition by a Synthetic Nicotinamide Cofactor Biomimetic
por: Kailing, Lyn L., et al.
Publicado: (2018)

Selection of a Mimotope Peptide of S-adenosyl-l-homocysteine and Its Application in Immunoassays
por: Wu, Chun, et al.
Publicado: (2013)

Crystallographic and SAXS studies of S-adenosyl-l-homocysteine hydrolase from Bradyrhizobium elkanii
por: Manszewski, Tomasz, et al.
Publicado: (2017)

D-Glucosamine supplementation extends life span of nematodes and of ageing mice
por: Weimer, Sandra, et al.
Publicado: (2014)

Homocysteine as a Risk Factor for Atherosclerosis: Is Its Conversion to S-Adenosyl-L-Homocysteine the Key to Deregulated Lipid Metabolism?
por: Tehlivets, Oksana
Publicado: (2011)

Antagonizing Methuselah to extend life span
por: Alic, Nazif, et al.
Publicado: (2007)

Evolutionary conservation and post-translational control of S-adenosyl-L-homocysteine hydrolase in land plants
por: Alegre, Sara, et al.
Publicado: (2020)

S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling
por: Greco, Carolina Magdalen, et al.
Publicado: (2020)

dNAGLU Extends Life Span and Promotes Fitness and Stress Resistance in Drosophila
por: Xue, Rubing, et al.
Publicado: (2022)

S-adenosyl-l-homocysteine Hydrolase: A Structural Perspective on the Enzyme with Two Rossmann-Fold Domains
por: Brzezinski, Krzysztof
Publicado: (2020)

Clinical value and expression of Homer 1, homocysteine, S-adenosyl-l-homocysteine, fibroblast growth factors 23 in coronary heart disease
por: Zhang, Zhixin, et al.
Publicado: (2022)

Wumei Pill Ameliorates AOM/DSS-Induced Colitis-Associated Colon Cancer through Inhibition of Inflammation and Oxidative Stress by Regulating S-Adenosylhomocysteine Hydrolase- (AHCY-) Mediated Hedgehog Signaling in Mice
por: Wang, Jue, et al.
Publicado: (2022)

Rapamycin treatment during development extends life span and health span of male mice and Daphnia magna
por: Shindyapina, Anastasia V., et al.
Publicado: (2022)

S-adenosyl-L-homocysteine hydrolase FgSah1 is required for fungal development and virulence in Fusarium graminearum
por: Shi, Dongya, et al.
Publicado: (2021)

Nutrients and Pathways that Regulate Health Span and Life Span
por: Pignatti, Carla, et al.
Publicado: (2020)

Calorie Restriction Extends Life Span— But Which Calories?
por: Heilbronn, Leonie K, et al.
Publicado: (2005)

Subjective expansion of extended time-spans in experienced meditators
por: Wittmann, Marc, et al.
Publicado: (2015)

Reproductive Span of Caenorhabditis Elegans is Extended by Microbacterium Sp.
por: Le, Tho Son, et al.
Publicado: (2022)

Inhibition of S-adenosyl-L-homocysteine hydrolase alleviates alloimmune response by down-regulating CD4(+) T-cell activation in a mouse heart transplantation model
por: Huang, Yajun, et al.
Publicado: (2020)

Lamotrigine extends lifespan but compromises health span in Drosophila melanogaster
por: Avanesian, Agnesa, et al.
Publicado: (2009)

Rapamycin extends life- and health span because it slows aging
por: Blagosklonny, Mikhail V.
Publicado: (2013)

The life-span trajectory of visual perception of 3D objects
por: Freud, Erez, et al.
Publicado: (2017)

How to Slow down the Ticking Clock: Age-Associated Epigenetic Alterations and Related Interventions to Extend Life Span
por: Galow, Anne-Marie, et al.
Publicado: (2022)

S-Adenosyl-S-carboxymethyl-l-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA
por: Byrne, Robert T., et al.
Publicado: (2013)

S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase
por: Chen, Hui, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_6ft1i89t4cirjl0odr009fkqm7