Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level

Genetic association analyses of rare variants in next-generation sequencing (NGS) studies are fundamentally challenging due to the presence of a very large number of candidate variants at extremely low minor allele frequencies. Recent developments often focus on pooling multiple variants to provide...

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Detalles Bibliográficos
Autores principales: Jeng, Xinge Jessie, Daye, Zhongyin John, Lu, Wenbin, Tzeng, Jung-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927097/
https://www.ncbi.nlm.nih.gov/pubmed/27355347
http://dx.doi.org/10.1371/journal.pcbi.1004993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927097/
https://www.ncbi.nlm.nih.gov/pubmed/27355347
http://dx.doi.org/10.1371/journal.pcbi.1004993

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