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Rare Variants Association Analysis in Large-Scale Sequencing Studies at the Single Locus Level
Genetic association analyses of rare variants in next-generation sequencing (NGS) studies are fundamentally challenging due to the presence of a very large number of candidate variants at extremely low minor allele frequencies. Recent developments often focus on pooling multiple variants to provide...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927097/ https://www.ncbi.nlm.nih.gov/pubmed/27355347 http://dx.doi.org/10.1371/journal.pcbi.1004993 |