Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex

Complexin regulates spontaneous and activates Ca(2+)-triggered neurotransmitter release, yet the molecular mechanisms are still unclear. Here we performed single molecule fluorescence resonance energy transfer experiments and uncovered two conformations of complexin-1 bound to the ternary SNARE comp...

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Detalles Bibliográficos
Autores principales: Choi, Ucheor B, Zhao, Minglei, Zhang, Yunxiang, Lai, Ying, Brunger, Axel T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927292/
https://www.ncbi.nlm.nih.gov/pubmed/27253060
http://dx.doi.org/10.7554/eLife.16886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927292/
https://www.ncbi.nlm.nih.gov/pubmed/27253060
http://dx.doi.org/10.7554/eLife.16886

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