Cargando…

Sigma-1 Agonist Binding in the Aging Rat Brain: a MicroPET Study with [(11)C]SA4503

PURPOSE: Sigma-1 receptor ligands modulate the release of several neurotransmitters and intracellular calcium signaling. We examined the binding of a radiolabeled sigma-1 agonist in the aging rat brain with positron emission tomography (PET). PROCEDURES: Time-dependent uptake of [(11)C]SA4503 was me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramakrishnan, Nisha K., Visser, Anniek K. D., Rybczynska, Anna A., Nyakas, Csaba J., Luiten, Paul G. M., Kwizera, Chantal, Sijbesma, Jurgen W. A., Elsinga, Philip H., Ishiwata, Kiichi, Dierckx, Rudi A. J. O., van Waarde, Aren
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer US 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4927617/ https://www.ncbi.nlm.nih.gov/pubmed/26637208 http://dx.doi.org/10.1007/s11307-015-0917-6

Ejemplares similares

Steroid hormones affect binding of the sigma ligand (11)C-SA4503 in tumour cells and tumour-bearing rats
por: Rybczynska, Anna A., et al.
Publicado: (2009)

Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses
por: Sahlholm, Kristoffer, et al.
Publicado: (2015)

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP
por: Wang, Jing, et al.
Publicado: (2020)

Avenues to molecular imaging of dying cells: Focus on cancer
por: Rybczynska, Anna A., et al.
Publicado: (2018)

Novel Approach to Repeated Arterial Blood Sampling in Small Animal PET: Application in a Test-Retest Study with the Adenosine A1 Receptor Ligand [(11)C]MPDX
por: Sijbesma, Jürgen W. A., et al.
Publicado: (2016)

Test–Retest Repeatability of [(18)F]MC225-PET in Rodents: A Tracer for Imaging of P-gp Function
por: García-Varela, Lara, et al.
Publicado: (2020)

Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications
por: Visser, Anniek K. D., et al.
Publicado: (2010)

The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism
por: Liu, Xin, et al.
Publicado: (2019)

Corrigendum: The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism
por: Liu, Xin, et al.
Publicado: (2022)

SA4503, A Potent Sigma-1 Receptor Ligand, Ameliorates Synaptic Abnormalities and Cognitive Dysfunction in a Mouse Model of ATR-X Syndrome
por: Yamaguchi, Kouya, et al.
Publicado: (2018)

Hunting for the high‐affinity state of G‐protein‐coupled receptors with agonist tracers: Theoretical and practical considerations for positron emission tomography imaging
por: Shalgunov, Vladimir, et al.
Publicado: (2018)

Allosteric Interactions between Adenosine A(2A) and Dopamine D(2) Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging
por: Prasad, Kavya, et al.
Publicado: (2021)

PET/CT Imaging and Physiology of Mice on High Protein Diet
por: Sijbesma, Jürgen W. A., et al.
Publicado: (2021)

Pharmacokinetic Modeling of [(11)C]GSK-189254, PET Tracer Targeting H(3) Receptors, in Rat Brain
por: Ghazanfari, Nafiseh, et al.
Publicado: (2022)

Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo
por: de Bruyn, Marco, et al.
Publicado: (2010)

[(18)F]Atorvastatin Pharmacokinetics and Biodistribution in Healthy Female and Male Rats
por: Clemente, Gonçalo S., et al.
Publicado: (2021)

Binding of the Dual-Action Anti-Parkinsonian Drug AG-0029 to Dopamine D(2) and Histamine H(3) Receptors: A PET Study in Healthy Rats
por: Ghazanfari, Nafiseh, et al.
Publicado: (2022)

Is cyclooxygenase‐1 involved in neuroinflammation?
por: Ghazanfari, Nafiseh, et al.
Publicado: (2021)

Impact of an Adenosine A(2A) Receptor Agonist and Antagonist on Binding of the Dopamine D(2) Receptor Ligand [(11)C]raclopride in the Rodent Striatum
por: Prasad, Kavya, et al.
Publicado: (2022)

In Vivo Induction of P-Glycoprotein Function can be Measured with [(18)F]MC225 and PET
por: García-Varela, Lara, et al.
Publicado: (2021)

Effect of Dopamine D(2) Receptor Antagonists on [(18)F]-FEOBV Binding
por: Schildt, Anna, et al.
Publicado: (2020)

4503 Adaptation of Motor Action in Children with Hemiplegic Cerebral Palsy
por: Dimitropoulou, Katherine, et al.
Publicado: (2020)

Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective
por: S. Clemente, Gonçalo, et al.
Publicado: (2020)

Pharmacokinetic Modeling of (R)-[(11)C]verapamil to Measure the P-Glycoprotein Function in Nonhuman Primates
por: García-Varela, Lara, et al.
Publicado: (2020)

A new approach to produce [(18)F]MC225 via one-step synthesis, a PET radiotracer for measuring P-gp function
por: Garcia-Varela, Lara, et al.
Publicado: (2021)

The Acute and Early Effects of Whole-Brain Irradiation on Glial Activation, Brain Metabolism, and Behavior: a Positron Emission Tomography Study
por: Parente, Andrea, et al.
Publicado: (2020)

Preclinical Activity of the Vascular Disrupting Agent OXi4503 against Head and Neck Cancer
por: Bothwell, Katelyn D., et al.
Publicado: (2016)

Head-to-head comparison of (R)-[(11)C]verapamil and [(18)F]MC225 in non-human primates, tracers for measuring P-glycoprotein function
por: García-Varela, Lara, et al.
Publicado: (2021)

Pharmacokinetic Modeling of [(18)F]MC225 for Quantification of the P-Glycoprotein Function at the Blood–Brain Barrier in Non-Human Primates with PET
por: García-Varela, Lara, et al.
Publicado: (2020)

MicroSPECT and MicroPET Imaging of Small Animals for Drug Development
por: Jang, Beom-Su
Publicado: (2013)

An Optimized MicroPET Imaging Method for the Distribution and Synergies of Natural Products
por: Cui, Qingxin, et al.
Publicado: (2018)

Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes
por: Basheer, Loai, et al.
Publicado: (2015)

Evaluation of [(11)C]CB184 for imaging and quantification of TSPO overexpression in a rat model of herpes encephalitis
por: Vállez Garcia, David, et al.
Publicado: (2015)

PET Imaging with S-[(11)C]Methyl-L-Cysteine and L-[Methyl-(11)C]Methionine in Rat Models of Glioma, Glioma Radiotherapy, and Neuroinflammation
por: Parente, Andrea, et al.
Publicado: (2017)

Body distribution of (11)C-methionine and (18)FDG in rat measured by microPET
por: Štolc, Svorad, et al.
Publicado: (2011)

Using MicroPET Imaging in Quantitative Verification of the Acupuncture Effect in Ischemia Stroke Treatment
por: Liu, Huafeng, et al.
Publicado: (2013)

Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor
por: Fifis, Theodora, et al.
Publicado: (2013)

Biodistribution of andrographolide to assess the interior‐exterior relationship between the lung and intestine using microPET
por: Zhang, Qi, et al.
Publicado: (2020)

MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer’s Disease Model Mice
por: Kang, ShinWoo, et al.
Publicado: (2022)

Comparison of In Vitro Assays in Selecting Radiotracers for In Vivo P-Glycoprotein PET Imaging
por: Raaphorst, Renske M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_dv1hp40m705qnr15rulqc0rsml