Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors

As the activation of autophagy contributes to the efficacy of many anticancer therapies, deciphering the precise role of autophagy in cancer therapy is critical. Here, we report that the dual mTORC1/2 inhibitors PP242 and OSI-027 decreased cell viability but did not induce apoptosis in the non-small...

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Detalles Bibliográficos
Autores principales: Jin, Hyeon-Ok, Hong, Sung-Eun, Park, Jin-Ah, Chang, Yoon Hwan, Hong, Young Jun, Park, In-Chul, Lee, Jin Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928093/
https://www.ncbi.nlm.nih.gov/pubmed/27358039
http://dx.doi.org/10.1038/srep28945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928093/
https://www.ncbi.nlm.nih.gov/pubmed/27358039
http://dx.doi.org/10.1038/srep28945

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