CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma

Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating hypoxia-inducible factors-1α (HIF-1α) and -2α (HI...

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Detalles Bibliográficos
Autores principales: Schokrpur, Shiruyeh, Hu, Junhui, Moughon, Diana L., Liu, Peijun, Lin, Lucia C., Hermann, Kip, Mangul, Serghei, Guan, Wei, Pellegrini, Matteo, Xu, Hua, Wu, Lily
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928183/
https://www.ncbi.nlm.nih.gov/pubmed/27358011
http://dx.doi.org/10.1038/srep29032

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928183/
https://www.ncbi.nlm.nih.gov/pubmed/27358011
http://dx.doi.org/10.1038/srep29032

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