Cargando…

CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma

Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating hypoxia-inducible factors-1α (HIF-1α) and -2α (HI...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schokrpur, Shiruyeh, Hu, Junhui, Moughon, Diana L., Liu, Peijun, Lin, Lucia C., Hermann, Kip, Mangul, Serghei, Guan, Wei, Pellegrini, Matteo, Xu, Hua, Wu, Lily
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928183/ https://www.ncbi.nlm.nih.gov/pubmed/27358011 http://dx.doi.org/10.1038/srep29032

Ejemplares similares

A Non-integrating Lentiviral Approach Overcomes Cas9-Induced Immune Rejection to Establish an Immunocompetent Metastatic Renal Cancer Model
por: Hu, Junhui, et al.
Publicado: (2018)

Tumor heterogeneity in VHL drives metastasis in clear cell renal cell carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

The splicing regulatory element, UGCAUG, is phylogenetically and spatially conserved in introns that flank tissue-specific alternative exons
por: Minovitsky, Simon, et al.
Publicado: (2005)

VHL L169P Variant Does Not Alter Cellular Hypoxia Tension in Clear Cell Renal Cell Carcinoma
por: Hu, Junhui, et al.
Publicado: (2023)

In vivo profiling of metastatic double knockouts through CRISPR-Cpf1 screens
por: Chow, Ryan D., et al.
Publicado: (2019)

CRISPR/Cas9 Methodology for the Generation of Knockout Deletions in Caenorhabditis elegans
por: Au, Vinci, et al.
Publicado: (2018)

The Gene Expression Deconvolution Interactive Tool (GEDIT): accurate cell type quantification from gene expression data
por: Nadel, Brian B, et al.
Publicado: (2021)

MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
por: Bhaumik, Dipa, et al.
Publicado: (2009)

Deciphering von Hippel-Lindau (VHL/Vhl)-Associated Pancreatic Manifestations by Inactivating Vhl in Specific Pancreatic Cell Populations
por: Shen, H.-C. Jennifer, et al.
Publicado: (2009)

Determination of the consequences of VHL mutations on VHL transcripts in renal cell carcinoma
por: TAYLOR, CLAIRE, et al.
Publicado: (2012)

One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
por: Hai, Tang, et al.
Publicado: (2014)

Generation of Gene-Knockout Mongolian Gerbils via CRISPR/Cas9 System
por: Wang, Yan, et al.
Publicado: (2020)

Generation of gene-of-interest knockouts in murine organoids using CRISPR-Cas9
por: Huber, Anne, et al.
Publicado: (2023)

Loss of Von Hippel–Lindau (VHL) Tumor Suppressor Gene Function: VHL–HIF Pathway and Advances in Treatments for Metastatic Renal Cell Carcinoma (RCC)
por: Kim, Hyunho, et al.
Publicado: (2021)

Improving the usability and archival stability of bioinformatics software
por: Mangul, Serghei, et al.
Publicado: (2019)

TAMPA: interpretable analysis and visualization of metagenomics-based taxon abundance profiles
por: Sarwal, Varuni, et al.
Publicado: (2023)

Identification of 3 novel VHL germ-line mutations in Danish VHL patients
por: Dandanell, Mette, et al.
Publicado: (2012)

CRISPR/Cas9-mediated generation of a Plac8 knockout mouse model
por: Lee, HyunJeong, et al.
Publicado: (2018)

Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering
por: Horii, Takuro, et al.
Publicado: (2014)

krCRISPR: an easy and efficient strategy for generating conditional knockout of essential genes in cells
por: Wang, Bei, et al.
Publicado: (2019)

Generating Single Cell–Derived Knockout Clones in Mammalian Cells with CRISPR/Cas9
por: Giuliano, Christopher J., et al.
Publicado: (2019)

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein (RNP) electroporation
por: Gim, Gyeong-Min, et al.
Publicado: (2023)

Generation of gene-of-interest double allele knockout clones in primary human T cells by CRISPR
por: Wu, Ling, et al.
Publicado: (2023)

Estimation of alternative splicing isoform frequencies from RNA-Seq data
por: Nicolae, Marius, et al.
Publicado: (2011)

Hidden treasures in contemporary RNA sequencing
por: Mangul, Serghei, et al.
Publicado: (2019)

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma
por: McRonald, Fiona E, et al.
Publicado: (2009)

Computational and Experimental Characterization of dVHL Establish a Drosophila Model of VHL Syndrome
por: Shmueli, Merav D., et al.
Publicado: (2014)

Rapamycin Enhances Adenovirus-Mediated Cancer Imaging and Therapy in Pre-Immunized Murine Hosts
por: Jiang, Ziyue Karen, et al.
Publicado: (2013)

Dynamic epigenetic changes to VHL occur with sunitinib in metastatic clear cell renal cancer
por: Stewart, Grant D., et al.
Publicado: (2016)

VHL-P138R and VHL-L163R Novel Variants: Mechanisms of VHL Pathogenicity Involving HIF-Dependent and HIF-Independent Actions
por: Mathó, Cecilia, et al.
Publicado: (2022)

CRISPR-Trap: a clean approach for the generation of gene knockouts and gene replacements in human cells
por: Reber, Stefan, et al.
Publicado: (2018)

Generation and Phenotype Identification of PAX4 Gene Knockout Rabbit by CRISPR/Cas9 System
por: Xu, Yuanyuan, et al.
Publicado: (2018)

Rapid Generation of Long Noncoding RNA Knockout Mice Using CRISPR/Cas9 Technology
por: Hansmeier, Nils R., et al.
Publicado: (2019)

Efficient and specific generation of knockout mice using Campylobacter jejuni CRISPR/Cas9 system
por: Lee, Jae Young, et al.
Publicado: (2020)

An efficient and precise method for generating knockout cell lines based on CRISPR‐Cas9 system
por: Lu, Xibin, et al.
Publicado: (2020)

Generation and Characterization of a CRISPR/Cas9-Mediated SNAP29 Knockout in Human Fibroblasts
por: Martens, Marie Christine, et al.
Publicado: (2021)

TRIP: a method for novel transcript reconstruction from paired-end RNA-seq reads
por: Mangul, Serghei, et al.
Publicado: (2012)

Metalign: efficient alignment-based metagenomic profiling via containment min hash
por: LaPierre, Nathan, et al.
Publicado: (2020)

Response to ‘comment on rigorous benchmarking of T cell receptor repertoire profiling methods for cancer RNA sequencing’ by Davydov A.N.; Bolotin D.A.; Poslavsky S. V. and Chudakov D.M.
por: Huang, Yu-Ning, et al.
Publicado: (2023)

Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting
por: Li, Ze, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_r6qdubohdvk8mk8nkggbrb2sj2