p27(KIP1) and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice

PTEN acts as a phosphatase for PIP3 and negatively regulates the PI3K/AKT pathway, and p27(KIP1) is a cyclin-dependent kinase inhibitor that regulates the G1 to S-phase transition by binding to and regulating the activity of cyclin-dependent kinases. Genetic alterations of PTEN or CDKN1B (p27(KIP1))...

Descripción completa

Detalles Bibliográficos
Autores principales: Shao, Jingchen, Li, Susann, Palmqvist, Lars, Fogelstrand, Linda, Wei, Stella Y., Busayavalasa, Kiran, Liu, Kui, Liu, Viktor M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928343/
https://www.ncbi.nlm.nih.gov/pubmed/27366593
http://dx.doi.org/10.1186/s40164-016-0047-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928343/
https://www.ncbi.nlm.nih.gov/pubmed/27366593
http://dx.doi.org/10.1186/s40164-016-0047-0

Ejemplares similares