Antibodies to the RNA Binding Protein Heterogeneous Nuclear Ribonucleoprotein A1 Colocalize to Stress Granules Resulting in Altered RNA and Protein Levels in a Model of Neurodegeneration in Multiple Sclerosis

OBJECTIVE: Multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS). Data suggest that antibodies to CNS targets contribute to the pathogenesis of MS. MS patients produce autoantibodies to heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1). hnRNP A1 is...

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Detalles Bibliográficos
Autores principales: Douglas, Joshua N., Gardner, Lidia A., Salapa, Hannah E, Levin, Michael C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928374/
https://www.ncbi.nlm.nih.gov/pubmed/27375925
http://dx.doi.org/10.4172/2155-9899.1000402

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928374/
https://www.ncbi.nlm.nih.gov/pubmed/27375925
http://dx.doi.org/10.4172/2155-9899.1000402

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