Acute Stress Responses Are Early Molecular Events of Retinal Degeneration in Abca4(−/−)Rdh8(−/−) Mice After Light Exposure

PURPOSE: Mice lacking ATP-binding cassette transporter 4 (ABCA4) and retinol dehydrogenase 8 (RDH8) mimic features of human Stargardt disease and age-related macular degeneration. RNA-sequencing of whole eyes was done to study early gene expression changes in Abca4(−/−)Rdh8(−/−) mice. METHODS: Abca4...

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Detalles Bibliográficos
Autores principales: Parmar, Tanu, Parmar, Vipul M., Arai, Eisuke, Sahu, Bhubanananda, Perusek, Lindsay, Maeda, Akiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2016
Materias:
Retinal Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928696/
https://www.ncbi.nlm.nih.gov/pubmed/27315541
http://dx.doi.org/10.1167/iovs.15-18993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928696/
https://www.ncbi.nlm.nih.gov/pubmed/27315541
http://dx.doi.org/10.1167/iovs.15-18993

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