[Nle(4), D-Phe(7)]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype

α-melanocyte stimulating hormone (α-MSH) is an anti-inflammatory peptide, proved to be beneficial in many neuroinflammatory disorders acting through melanocortin receptor 4 (MC4R). We previously determined that rat microglial cells express MC4R and that NDP-MSH, an analog of α-MSH, induces PPAR-γ ex...

Descripción completa

Detalles Bibliográficos
Autores principales: Carniglia, Lila, Ramírez, Delia, Durand, Daniela, Saba, Julieta, Caruso, Carla, Lasaga, Mercedes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928783/
https://www.ncbi.nlm.nih.gov/pubmed/27359332
http://dx.doi.org/10.1371/journal.pone.0158564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928783/
https://www.ncbi.nlm.nih.gov/pubmed/27359332
http://dx.doi.org/10.1371/journal.pone.0158564

Ejemplares similares