The Meiotic Recombination Activator PRDM9 Trimethylates Both H3K36 and H3K4 at Recombination Hotspots In Vivo

In many mammals, including humans and mice, the zinc finger histone methyltransferase PRDM9 performs the first step in meiotic recombination by specifying the locations of hotspots, the sites of genetic recombination. PRDM9 binds to DNA at hotspots through its zinc finger domain and activates recomb...

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Detalles Bibliográficos
Autores principales: Powers, Natalie R., Parvanov, Emil D., Baker, Christopher L., Walker, Michael, Petkov, Petko M., Paigen, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928815/
https://www.ncbi.nlm.nih.gov/pubmed/27362481
http://dx.doi.org/10.1371/journal.pgen.1006146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928815/
https://www.ncbi.nlm.nih.gov/pubmed/27362481
http://dx.doi.org/10.1371/journal.pgen.1006146

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