Genomic agonism and phenotypic antagonism between estrogen and progesterone receptors in breast cancer

The functional role of progesterone receptor (PR) and its impact on estrogen signaling in breast cancer remain controversial. In primary ER(+) (estrogen receptor–positive)/PR(+) human tumors, we report that PR reprograms estrogen signaling as a genomic agonist and a phenotypic antagonist. In isolati...

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Detalles Bibliográficos
Autores principales: Singhal, Hari, Greene, Marianne E., Tarulli, Gerard, Zarnke, Allison L., Bourgo, Ryan J., Laine, Muriel, Chang, Ya-Fang, Ma, Shihong, Dembo, Anna G., Raj, Ganesh V., Hickey, Theresa E., Tilley, Wayne D., Greene, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928895/
https://www.ncbi.nlm.nih.gov/pubmed/27386569
http://dx.doi.org/10.1126/sciadv.1501924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4928895/
https://www.ncbi.nlm.nih.gov/pubmed/27386569
http://dx.doi.org/10.1126/sciadv.1501924

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