A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression

Multiple human diseases are associated with a liquid-to-solid phase transition resulting in the formation of amyloid fibers or protein aggregates. Here, we present an alternative mechanism for cellular toxicity based on a concentration-dependent liquid-liquid demixing. Analyzing proteins that are to...

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Detalles Bibliográficos
Autores principales: Bolognesi, Benedetta, Lorenzo Gotor, Nieves, Dhar, Riddhiman, Cirillo, Davide, Baldrighi, Marta, Tartaglia, Gian Gaetano, Lehner, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929146/
https://www.ncbi.nlm.nih.gov/pubmed/27320918
http://dx.doi.org/10.1016/j.celrep.2016.05.076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929146/
https://www.ncbi.nlm.nih.gov/pubmed/27320918
http://dx.doi.org/10.1016/j.celrep.2016.05.076

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