Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation

KEY POINTS: Hyperekplexia or startle disease is a serious neurological condition affecting newborn children and usually involves dysfunctional glycinergic neurotransmission. Glycine receptors (GlyRs) are major mediators of inhibition in the spinal cord and brainstem. A missense mutation, replacing a...

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Detalles Bibliográficos
Autores principales: Wilkins, Megan E., Caley, Alex, Gielen, Marc C., Harvey, Robert J., Smart, Trevor G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Neuroscience ‐ cellular/molecular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929309/
https://www.ncbi.nlm.nih.gov/pubmed/27028707
http://dx.doi.org/10.1113/JP272122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929309/
https://www.ncbi.nlm.nih.gov/pubmed/27028707
http://dx.doi.org/10.1113/JP272122

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