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Murine startle mutant Nmf11 affects the structural stability of the glycine receptor and increases deactivation
KEY POINTS: Hyperekplexia or startle disease is a serious neurological condition affecting newborn children and usually involves dysfunctional glycinergic neurotransmission. Glycine receptors (GlyRs) are major mediators of inhibition in the spinal cord and brainstem. A missense mutation, replacing a...
Autores principales: | Wilkins, Megan E., Caley, Alex, Gielen, Marc C., Harvey, Robert J., Smart, Trevor G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929309/ https://www.ncbi.nlm.nih.gov/pubmed/27028707 http://dx.doi.org/10.1113/JP272122 |
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