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The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond

The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks o...

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Detalles Bibliográficos
Autores principales: Wilson, Kayla E., Yang, Nuo, Mussell, Ashley L., Zhang, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929422/
https://www.ncbi.nlm.nih.gov/pubmed/27240404
http://dx.doi.org/10.3390/genes7060023
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author Wilson, Kayla E.
Yang, Nuo
Mussell, Ashley L.
Zhang, Jianmin
author_facet Wilson, Kayla E.
Yang, Nuo
Mussell, Ashley L.
Zhang, Jianmin
author_sort Wilson, Kayla E.
collection PubMed
description The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks of intracellular and extracellular signaling pathways that modulate YAP and TAZ activities have recently been identified. Among them, KIBRA and PTPN14 are two evolutionarily-conserved and important YAP/TAZ upstream regulators. They can negatively regulate YAP/TAZ functions separately or in concert. In this review, we summarize the current and emerging regulatory roles of KIBRA and PTPN14 in the Hippo pathway and their functions in cancer.
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spelling pubmed-49294222016-07-07 The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond Wilson, Kayla E. Yang, Nuo Mussell, Ashley L. Zhang, Jianmin Genes (Basel) Review The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks of intracellular and extracellular signaling pathways that modulate YAP and TAZ activities have recently been identified. Among them, KIBRA and PTPN14 are two evolutionarily-conserved and important YAP/TAZ upstream regulators. They can negatively regulate YAP/TAZ functions separately or in concert. In this review, we summarize the current and emerging regulatory roles of KIBRA and PTPN14 in the Hippo pathway and their functions in cancer. MDPI 2016-05-27 /pmc/articles/PMC4929422/ /pubmed/27240404 http://dx.doi.org/10.3390/genes7060023 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wilson, Kayla E.
Yang, Nuo
Mussell, Ashley L.
Zhang, Jianmin
The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title_full The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title_fullStr The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title_full_unstemmed The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title_short The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond
title_sort regulatory role of kibra and ptpn14 in hippo signaling and beyond
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929422/
https://www.ncbi.nlm.nih.gov/pubmed/27240404
http://dx.doi.org/10.3390/genes7060023
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