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Inhibition of hypoxia inducible factor-1α attenuates abdominal aortic aneurysm progression through the down-regulation of matrix metalloproteinases
Hypoxia inducible factor-1α (HIF-1α) pathway is associated with many vascular diseases, including atherosclerosis, arterial aneurysms, pulmonary hypertension and chronic venous diseases. Significant HIF-1α expression could be found at the rupture edge at human abdominal aortic aneurysm (AAA) tissues...
Autores principales: | Tsai, Shih-Hung, Huang, Po-Hsun, Hsu, Yu-Juei, Peng, Yi-Jen, Lee, Chien-Hsing, Wang, Jen-Chun, Chen, Jaw-Wen, Lin, Shing-Jong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929442/ https://www.ncbi.nlm.nih.gov/pubmed/27363580 http://dx.doi.org/10.1038/srep28612 |
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