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Polysaccharide Nanoparticles for Efficient siRNA Targeting in Cancer Cells by Supramolecular pK(a) Shift

Biomacromolecular pK(a) shifting is considered as one of the most ubiquitous processes in biochemical events, e.g., the enzyme-catalyzed reaction and protein conformational stabilization. In this paper, we report on the construction of biocompatible polysaccharide nanoparticle with targeting ability...

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Detalles Bibliográficos
Autores principales: Zhang, Ying-Ming, Yang, Yang, Zhang, Yu-Hui, Liu, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929451/
https://www.ncbi.nlm.nih.gov/pubmed/27363811
http://dx.doi.org/10.1038/srep28848