The p53 tetramer shows an induced-fit interaction of the C-terminal domain with the DNA-binding domain

The Trp53 gene is the most frequently mutated gene in all human cancers. Its protein product p53 is a very powerful transcription factor that can activate different biochemical pathways and affect the regulation of metabolism, senescence, DNA damage response, cell cycle and cell death. The understan...

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Detalles Bibliográficos
Autores principales: D'Abramo, M, Bešker, N, Desideri, A, Levine, A J, Melino, G, Chillemi, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929483/
https://www.ncbi.nlm.nih.gov/pubmed/26477317
http://dx.doi.org/10.1038/onc.2015.388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929483/
https://www.ncbi.nlm.nih.gov/pubmed/26477317
http://dx.doi.org/10.1038/onc.2015.388

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