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Organelle acidification negatively regulates vacuole membrane fusion in vivo

The V-ATPase is a proton pump consisting of a membrane-integral V(0) sector and a peripheral V(1) sector, which carries the ATPase activity. In vitro studies of yeast vacuole fusion and evidence from worms, flies, zebrafish and mice suggested that V(0) interacts with the SNARE machinery for membrane...

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Detalles Bibliográficos
Autores principales: Desfougères, Yann, Vavassori, Stefano, Rompf, Maria, Gerasimaite, Ruta, Mayer, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929563/
https://www.ncbi.nlm.nih.gov/pubmed/27363625
http://dx.doi.org/10.1038/srep29045