Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)

Glutaminase is a metabolic enzyme responsible for glutaminolysis, a process harnessed by cancer cells to feed their accelerated growth and proliferation. Among the glutaminase isoforms, human kidney-type glutaminase (KGA) is often upregulated in cancer and is thus touted as an attractive drug target...

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Detalles Bibliográficos
Autores principales: Thangavelu, K., Chong, Qing Yun, Low, Boon Chuan, Sivaraman, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929687/
https://www.ncbi.nlm.nih.gov/pubmed/24451979
http://dx.doi.org/10.1038/srep03827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929687/
https://www.ncbi.nlm.nih.gov/pubmed/24451979
http://dx.doi.org/10.1038/srep03827

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