Concurrent progress of reprogramming and gene correction to overcome therapeutic limitation of mutant ALK2-iPSC

Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1, encoding a constitutive active bone morphogenetic protein type I receptor (also called ALK2) to induce heterotopic ossification in the patient. To genetically correct it, we attempted to generate the mutant...

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Detalles Bibliográficos
Autores principales: Kim, Bu-Yeo, Jeong, SangKyun, Lee, Seo-Young, Lee, So Min, Gweon, Eun Jeong, Ahn, Hyunjun, Kim, Janghwan, Chung, Sun-Ku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929693/
https://www.ncbi.nlm.nih.gov/pubmed/27256111
http://dx.doi.org/10.1038/emm.2016.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929693/
https://www.ncbi.nlm.nih.gov/pubmed/27256111
http://dx.doi.org/10.1038/emm.2016.43

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