The effect of HIV-1 Vif polymorphisms on A3G anti-viral activity in an in vivo mouse model

Humans encode seven APOBEC3 proteins (A–H), with A3G, 3F and 3H as the major factors restricting HIV-1 replication. HIV-1, however, encodes Vif, which counteracts A3 proteins by chaperoning them to the proteasome where they are degraded. Vif polymorphisms found in HIV-1s isolated from infected patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Cadena, Cristhian, Stavrou, Spyridon, Manzoni, Tomaz, Iyer, Shilpa S., Bibollet-Ruche, Frederic, Zhang, Weiyu, Hahn, Beatrice H., Browne, Edward P., Ross, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929759/
https://www.ncbi.nlm.nih.gov/pubmed/27363431
http://dx.doi.org/10.1186/s12977-016-0280-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929759/
https://www.ncbi.nlm.nih.gov/pubmed/27363431
http://dx.doi.org/10.1186/s12977-016-0280-y

Ejemplares similares