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Absence of systemic oxidative stress and increased CSF prostaglandin F(2α) in progressive MS

OBJECTIVE: We aimed to investigate the role of oxidative stress in the progression of multiple sclerosis (MS). METHODS: We determined by liquid chromatography–tandem mass spectrometry nonenzymatic (F(2)-isoprostanes) and enzymatic oxidation products of arachidonic acid (prostaglandin F(2α) [PGF(2α)]...

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Detalles Bibliográficos
Autores principales: Lam, Magda A., Maghzal, Ghassan J., Khademi, Mohsen, Piehl, Fredik, Ratzer, Rikke, Romme Christensen, Jeppe, Sellebjerg, Finn Thorup, Olsson, Tomas, Stocker, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929888/
https://www.ncbi.nlm.nih.gov/pubmed/27386506
http://dx.doi.org/10.1212/NXI.0000000000000256