Cargando…
How Can Viral Dynamics Models Inform Endpoint Measures in Clinical Trials of Therapies for Acute Viral Infections?
Acute viral infections pose many practical challenges for the accurate assessment of the impact of novel therapies on viral growth and decay. Using the example of influenza A, we illustrate how the measurement of infection-related quantities that determine the dynamics of viral load within the human...
Autores principales: | Vegvari, Carolin, Hadjichrysanthou, Christoforos, Cauët, Emilie, Lawrence, Emma, Cori, Anne, de Wolf, Frank, Anderson, Roy M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930163/ https://www.ncbi.nlm.nih.gov/pubmed/27367230 http://dx.doi.org/10.1371/journal.pone.0158237 |
Ejemplares similares
-
Using Clinical Trial Simulators to Analyse the Sources of Variance in Clinical Trials of Novel Therapies for Acute Viral Infections
por: Vegvari, Carolin, et al.
Publicado: (2016) -
Understanding the within-host dynamics of influenza A virus: from theory to clinical implications
por: Hadjichrysanthou, Christoforos, et al.
Publicado: (2016) -
A Systematic Review of Longitudinal Studies Which Measure Alzheimer’s Disease Biomarkers
por: Lawrence, Emma, et al.
Publicado: (2017) -
The importance of endpoint selection: How effective does a drug need to be for success in a clinical trial of a possible Alzheimer’s disease treatment?
por: Evans, Stephanie, et al.
Publicado: (2018) -
SARS‐CoV‐2 viral dynamic modeling to inform model selection and timing and efficacy of antiviral therapy
por: Zhang, Shengyuan, et al.
Publicado: (2023)