Tuberculosis Therapy Modifies the Cytokine Profile, Maturation State, and Expression of Inhibitory Molecules on Mycobacterium tuberculosis-Specific CD4(+) T-Cells

BACKGROUND: Little is known about the expression of inhibitory molecules cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed-death-1 (PD-1) on Mycobacterium tuberculosis (Mtb)-specific CD4 T-cells and how their expression is impacted by TB treatment. METHODS: Cryopreserved PBMCs from HIV-TB co-...

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Detalles Bibliográficos
Autores principales: Saharia, Kapil K., Petrovas, Constantinos, Ferrando-Martinez, Sara, Leal, Manuel, Luque, Rafael, Ive, Prudence, Luetkemeyer, Anne, Havlir, Diane, Koup, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930205/
https://www.ncbi.nlm.nih.gov/pubmed/27367521
http://dx.doi.org/10.1371/journal.pone.0158262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930205/
https://www.ncbi.nlm.nih.gov/pubmed/27367521
http://dx.doi.org/10.1371/journal.pone.0158262

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