Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer

BACKGROUND: High mitotic activity is associated with the genesis and progression of many cancers. Small molecule inhibitors of mitotic apparatus proteins are now being developed and evaluated clinically as anticancer agents. With clinical trials of several of these experimental compounds underway, i...

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Detalles Bibliográficos
Autores principales: Hu, Zhi, Mao, Jian-Hua, Curtis, Christina, Huang, Ge, Gu, Shenda, Heiser, Laura, Lenburg, Marc E., Korkola, James E., Bayani, Nora, Samarajiwa, Shamith, Seoane, Jose A., A. Dane, Mark, Esch, Amanda, Feiler, Heidi S., Wang, Nicholas J., Hardwicke, Mary Ann, Laquerre, Sylvie, Jackson, Jeff, W. Wood, Kenneth, Weber, Barbara, Spellman, Paul T., Aparicio, Samuel, Wooster, Richard, Caldas, Carlos, Gray, Joe W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930593/
https://www.ncbi.nlm.nih.gov/pubmed/27368372
http://dx.doi.org/10.1186/s13058-016-0728-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930593/
https://www.ncbi.nlm.nih.gov/pubmed/27368372
http://dx.doi.org/10.1186/s13058-016-0728-y

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