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Investigation of allosteric coupling in human β(2)-adrenergic receptor in the presence of intracellular loop 3

BACKGROUND: This study investigates the allosteric coupling that exists between the intra- and extracellular parts of human β(2)-adrenergic receptor (β(2)-AR), in the presence of the intracellular loop 3 (ICL3), which is missing in all crystallographic experiments and most of the simulation studies...

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Detalles Bibliográficos
Autores principales: Ozgur, Canan, Doruker, Pemra, Akten, E. Demet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930610/
https://www.ncbi.nlm.nih.gov/pubmed/27368374
http://dx.doi.org/10.1186/s12900-016-0061-9