Host miRNA degradation by Herpesvirus saimiri small nuclear RNA requires an unstructured interacting region

Herpesvirus saimiri, an oncogenic herpesvirus, during latency produces seven small nuclear RNAs, called the Herpesvirus saimiri U RNAs (HSUR1–7). HSUR1 mediates degradation of the host microRNA, miR-27, via a process that requires imperfect base-pairing. The decreased levels of miR-27 lead to prolon...

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Detalles Bibliográficos
Autores principales: Pawlica, Paulina, Moss, Walter N., Steitz, Joan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931111/
https://www.ncbi.nlm.nih.gov/pubmed/27335146
http://dx.doi.org/10.1261/rna.054817.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931111/
https://www.ncbi.nlm.nih.gov/pubmed/27335146
http://dx.doi.org/10.1261/rna.054817.115

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