Defects in THO/TREX-2 function cause accumulation of novel cytoplasmic mRNP granules that can be cleared by autophagy

The nuclear THO and TREX-2 complexes are implicated in several steps of nuclear mRNP biogenesis, including transcription, 3′ end processing and export. In a recent genomic microscopy screen in Saccharomyces cerevisiae for mutants with constitutive stress granules, we identified that absence of THO a...

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Detalles Bibliográficos
Autores principales: Eshleman, Nichole, Liu, Guangbo, McGrath, Kaitlyn, Parker, Roy, Buchan, J. Ross
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931113/
https://www.ncbi.nlm.nih.gov/pubmed/27251550
http://dx.doi.org/10.1261/rna.057224.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931113/
https://www.ncbi.nlm.nih.gov/pubmed/27251550
http://dx.doi.org/10.1261/rna.057224.116

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