Transcriptomic comparison of Drosophila snRNP biogenesis mutants reveals mutant-specific changes in pre-mRNA processing: implications for spinal muscular atrophy

Survival motor neuron (SMN) functions in the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs) that catalyze pre-mRNA splicing. Here, we used disruptions in Smn and two additional snRNP biogenesis genes, Phax and Ars2, to classify RNA processing differences as snRNP-dependent or gen...

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Detalles Bibliográficos
Autores principales: Garcia, Eric L., Wen, Ying, Praveen, Kavita, Matera, A. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931114/
https://www.ncbi.nlm.nih.gov/pubmed/27268418
http://dx.doi.org/10.1261/rna.057208.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931114/
https://www.ncbi.nlm.nih.gov/pubmed/27268418
http://dx.doi.org/10.1261/rna.057208.116

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