Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally rede...

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Detalles Bibliográficos
Autores principales: Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931249/
https://www.ncbi.nlm.nih.gov/pubmed/27349805
http://dx.doi.org/10.1038/ncomms12040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931249/
https://www.ncbi.nlm.nih.gov/pubmed/27349805
http://dx.doi.org/10.1038/ncomms12040

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