Cargando…

Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability

The trimeric HIV-1 envelope glycoprotein (Env) is critical for host immune recognition and neutralization. Despite advances in trimer design, the roots of Env trimer metastability remain elusive. Here we investigate the contribution of two Env regions to metastability. First, we computationally rede...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kong, Leopold, He, Linling, de Val, Natalia, Vora, Nemil, Morris, Charles D., Azadnia, Parisa, Sok, Devin, Zhou, Bin, Burton, Dennis R., Ward, Andrew B., Wilson, Ian A., Zhu, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931249/ https://www.ncbi.nlm.nih.gov/pubmed/27349805 http://dx.doi.org/10.1038/ncomms12040

Ejemplares similares

Differential Antibody Responses to Conserved HIV-1 Neutralizing Epitopes in the Context of Multivalent Scaffolds and Native-Like gp140 Trimers
por: Morris, Charles D., et al.
Publicado: (2017)

Single-component multilayered self-assembling protein nanoparticles presenting glycan-trimmed uncleaved prefusion optimized envelope trimers as HIV-1 vaccine candidates
por: Zhang, Yi-Nan, et al.
Publicado: (2023)

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles
por: He, Linling, et al.
Publicado: (2016)

Hidden Lineage Complexity of Glycan-Dependent HIV-1 Broadly Neutralizing Antibodies Uncovered by Digital Panning and Native-Like gp140 Trimer
por: He, Linling, et al.
Publicado: (2017)

Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer
por: Mao, Youdong, et al.
Publicado: (2013)

Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases
por: Olia, Adam S., et al.
Publicado: (2023)

P19-23. Putative prefusion mechanism of HIV-1 Env revealed by ligand-induced quaternary alterations in o-gp140 trimers
por: Moscoso, CG, et al.
Publicado: (2009)

HIV-1 vaccine design through minimizing envelope metastability
por: He, Linling, et al.
Publicado: (2018)

Selection of nanobodies with broad neutralizing potential against primary HIV-1 strains using soluble subtype C gp140 envelope trimers
por: Koch, Kathrin, et al.
Publicado: (2017)

Vaginal delivery of the recombinant HIV-1 clade-C trimeric gp140 envelope protein CN54gp140 within novel rheologically structured vehicles elicits specific immune responses
por: Curran, Rhonda M., et al.
Publicado: (2009)

Neutralizing Antibodies Induced by First-Generation gp41-Stabilized HIV-1 Envelope Trimers and Nanoparticles
por: Kumar, Sonu, et al.
Publicado: (2021)

Transient opening of trimeric prefusion RSV F proteins
por: Gilman, Morgan S. A., et al.
Publicado: (2019)

Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits
por: Yasmeen, Anila, et al.
Publicado: (2014)

Structure and immune recognition of trimeric prefusion HIV-1 Env
por: Pancera, Marie, et al.
Publicado: (2014)

Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers
por: Rutten, Lucy, et al.
Publicado: (2020)

Characterization and Immunogenicity of HIV Envelope gp140 Zera(®) Tagged Antigens
por: Ximba, Phindile, et al.
Publicado: (2020)

Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation
por: Yin, Hsien-Sheng, et al.
Publicado: (2006)

Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer
por: Cao, Liwei, et al.
Publicado: (2018)

Antigenicity of soluble HIV gp140 trimers reveals differences in solution conformation for differing HIV strains
por: Gearhart, TL, et al.
Publicado: (2012)

Enhanced Immunogenicity of HIV-1 Envelope gp140 Proteins Fused to APRIL
por: Isik, Gözde, et al.
Publicado: (2014)

Intravaginal immunization using the recombinant HIV-1 clade-C trimeric envelope glycoprotein CN54gp140 formulated within lyophilized solid dosage forms
por: Donnelly, Louise, et al.
Publicado: (2011)

HIV-1 neutralizing antibodies elicited in humans by a prefusion-stabilized envelope trimer form a reproducible class targeting fusion peptide
por: Wang, Shuishu, et al.
Publicado: (2023)

Inverse dose-response to gp140 YU2 foldon trimer formulated with aluminum phosphate and ISCOMATRIX® adjuvants
por: Wilson, A, et al.
Publicado: (2012)

Rational Design of DNA-Expressed Stabilized Native-Like HIV-1 Envelope Trimers
por: Aldon, Yoann, et al.
Publicado: (2018)

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
por: Voss, James E., et al.
Publicado: (2017)

Elicitation of Neutralizing Antibodies Targeting the V2 Apex of the HIV Envelope Trimer in a Wild-Type Animal Model
por: Voss, James E., et al.
Publicado: (2018)

One-step sequence and structure-guided optimization of HIV-1 envelope gp140
por: Malladi, Sameer Kumar, et al.
Publicado: (2020)

Structure of the rabies virus glycoprotein trimer bound to a prefusion-specific neutralizing antibody
por: Callaway, Heather M., et al.
Publicado: (2022)

Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state
por: Feng, Juan, et al.
Publicado: (2022)

Safety and immunogenicity of an HIV-1 prefusion-stabilized envelope trimer (Trimer 4571) vaccine in healthy adults: A first-in-human open-label, randomized, dose-escalation, phase 1 clinical trial
por: Houser, Katherine V., et al.
Publicado: (2022)

Toward a more accurate view of human B-cell repertoire by next-generation sequencing, unbiased repertoire capture and single-molecule barcoding
por: He, Linling, et al.
Publicado: (2014)

Transferrin conjugation confers mucosal molecular targeting to a model HIV-1 trimeric gp140 vaccine antigen()
por: Mann, J.F.S., et al.
Publicado: (2012)

Stability and neutralization capacity of a novel mosaic HIV-1 gp140 trimer in a guinea pig model
por: Nkolola, JP, et al.
Publicado: (2012)

Characterization of humoral responses to soluble trimeric HIV gp140 from a clade A Ugandan field isolate
por: Visciano, Maria Luisa, et al.
Publicado: (2013)

The Chimpanzee SIV Envelope Trimer: Structure and Deployment as an HIV Vaccine Template
por: Andrabi, Raiees, et al.
Publicado: (2019)

HIV-1 envelope trimer elicits higher neutralizing antibody responses than monomeric gp120
por: Kovacs, JM, et al.
Publicado: (2012)

Contribution of the gp120 V3 loop to envelope glycoprotein trimer stability in primate immunodeficiency viruses
por: Bowder, Dane, et al.
Publicado: (2018)

Antigenic and immunosuppressive properties of a trimeric recombinant transmembrane envelope protein gp41 of HIV-1
por: Mühle, Michael, et al.
Publicado: (2017)

Two Cholesterol Recognition Amino Acid Consensus Motifs of GP64 with Uncleaved Signal Peptide Are Required for Bombyx mori Nucleopolyhedrovirus Infection
por: Hao, Bifang, et al.
Publicado: (2021)

A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure
por: Lee, Jeong Hyun, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_el496kp7ce7ufbvrvrb92rrg15