Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer

Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lentivirus (LV...

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Detalles Bibliográficos
Autores principales: Jin, Chuan, Fotaki, Grammatiki, Ramachandran, Mohanraj, Nilsson, Berith, Essand, Magnus, Yu, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931286/
https://www.ncbi.nlm.nih.gov/pubmed/27189167
http://dx.doi.org/10.15252/emmm.201505869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931286/
https://www.ncbi.nlm.nih.gov/pubmed/27189167
http://dx.doi.org/10.15252/emmm.201505869

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