Cargando…

Safe engineering of CAR T cells for adoptive cell therapy of cancer using long‐term episomal gene transfer

Chimeric antigen receptor (CAR) T‐cell therapy is a new successful treatment for refractory B‐cell leukemia. Successful therapeutic outcome depends on long‐term expression of CAR transgene in T cells, which is achieved by delivering transgene using integrating gamma retrovirus (RV) or lentivirus (LV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Chuan, Fotaki, Grammatiki, Ramachandran, Mohanraj, Nilsson, Berith, Essand, Magnus, Yu, Di
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931286/ https://www.ncbi.nlm.nih.gov/pubmed/27189167 http://dx.doi.org/10.15252/emmm.201505869

Ejemplares similares

Systemic treatment with CAR-engineered T cells against PSCA delays subcutaneous tumor growth and prolongs survival of mice
por: Hillerdal, Victoria, et al.
Publicado: (2014)

Cancer vaccine based on a combination of an infection-enhanced adenoviral vector and pro-inflammatory allogeneic DCs leads to sustained antigen-specific immune responses in three melanoma models
por: Fotaki, Grammatiki, et al.
Publicado: (2017)

CAR T cells expressing a bacterial virulence factor trigger potent bystander antitumour responses in solid cancers
por: Jin, Chuan, et al.
Publicado: (2022)

Intratumoral administration of pro-inflammatory allogeneic dendritic cells improved the anti-tumor response of systemic anti-CTLA-4 treatment via unleashing a T cell-dependent response
por: Jin, Chuan, et al.
Publicado: (2022)

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
por: Fransson, Moa, et al.
Publicado: (2012)

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain
por: Rostami, Jinar, et al.
Publicado: (2020)

Adenovirus Serotype 5 Vectors with Tat-PTD Modified Hexon and Serotype 35 Fiber Show Greatly Enhanced Transduction Capacity of Primary Cell Cultures
por: Yu, Di, et al.
Publicado: (2013)

Complementarity-determining region clustering may cause CAR-T cell dysfunction
por: Sarén, Tina, et al.
Publicado: (2023)

Double-Detargeted Oncolytic Adenovirus Shows Replication Arrest in Liver Cells and Retains Neuroendocrine Cell Killing Ability
por: Leja, Justyna, et al.
Publicado: (2010)

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer
por: Ma, Jing, et al.
Publicado: (2020)

Tumor endothelial cell up-regulation of IDO1 is an immunosuppressive feed-back mechanism that reduces the response to CD40-stimulating immunotherapy
por: Georganaki, Maria, et al.
Publicado: (2020)

Single-Cell RNA Analysis Reveals Cell-Intrinsic Functions of CAR T Cells Correlating with Response in a Phase II Study of Lymphoma Patients
por: Sarén, Tina, et al.
Publicado: (2023)

An Infection-enhanced Oncolytic Adenovirus Secreting H. pylori Neutrophil-activating Protein with Therapeutic Effects on Neuroendocrine Tumors
por: Ramachandran, Mohanraj, et al.
Publicado: (2013)

From CARs to TRUCKs and Beyond: Safely en Route to Adoptive T-cell Therapy for Cancer
por: Dummy
Publicado: (2016)

Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer
por: Hillerdal, Victoria, et al.
Publicado: (2015)

Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells
por: Gómez-Moreno, Andoni, et al.
Publicado: (2023)

Of mice and lymphoid aggregates: modeling tertiary lymphoid structures in cancer
por: Vaccaro, Alessandra, et al.
Publicado: (2023)

Engineered CAR-Macrophages as Adoptive Immunotherapies for Solid Tumors
por: Sloas, Christopher, et al.
Publicado: (2021)

Adoptive Immunotherapy beyond CAR T-Cells
por: Titov, Aleksei, et al.
Publicado: (2021)

Bacterial episomes and plasmids;
Publicado: (1969)

Tertiary Lymphoid Structures in the Central Nervous System: Implications for Glioblastoma
por: van de Walle, Tiarne, et al.
Publicado: (2021)

IFN-I-tolerant oncolytic Semliki Forest virus in combination with anti-PD1 enhances T cell response against mouse glioma
por: Martikainen, Miika, et al.
Publicado: (2021)

Engineering CAR-T cells
por: Zhang, Cheng, et al.
Publicado: (2017)

Avidity characterization of genetically engineered T-cells with novel and established approaches
por: Hillerdal, Victoria, et al.
Publicado: (2016)

Nucleosome Positioning on Episomal Human Papillomavirus DNA in Cultured Cells
por: Murakami, Isao, et al.
Publicado: (2021)

Genetically engineered T cells for the treatment of cancer
por: Essand, M, et al.
Publicado: (2013)

Ixovex-1, a novel oncolytic E1B-mutated adenovirus
por: Anwar, Mohiemen, et al.
Publicado: (2022)

Engineering NK Cells for CAR Therapy—Recent Advances in Gene Transfer Methodology
por: Schmidt, Paula, et al.
Publicado: (2021)

Transpositionally active episomal hAT elements
por: O'Brochta, David A, et al.
Publicado: (2009)

Seatbelts in CAR therapy: How Safe Are CARS?
por: Minagawa, Kentaro, et al.
Publicado: (2015)

CAR-T Regulatory (CAR-Treg) Cells: Engineering and Applications
por: Arjomandnejad, Motahareh, et al.
Publicado: (2022)

Mesothelin-targeted CAR-T cells for adoptive cell therapy of solid tumors
por: Zhang, Gui-Zhen, et al.
Publicado: (2019)

Overcoming intrinsic inhibitory pathways to augment the antineoplastic activity of adoptively transferred T cells: Re-tuning your CAR before hitting a rocky road
por: Wang, Liang-Chuan S, et al.
Publicado: (2013)

Development of CAR-T Cell Persistence in Adoptive Immunotherapy of Solid Tumors
por: Fan, Jiaqiao, et al.
Publicado: (2021)

Gamma-Herpesvirus Latency Requires T Cell Evasion during Episome Maintenance
por: Bennett, Neil J, et al.
Publicado: (2005)

Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming
por: Schmitt, Christopher E., et al.
Publicado: (2017)

Episomal Induced Pluripotent Stem Cells: Functional and Potential Therapeutic Applications
por: Wang, Aline Yen Ling, et al.
Publicado: (2019)

Efficient tumor regression by adoptively transferred CEA-specific CAR-T cells associated with symptoms of mild cytokine release syndrome
por: Wang, Linan, et al.
Publicado: (2016)

The β-globin Replicator greatly enhances the potential of S/MAR based episomal vectors for gene transfer into human haematopoietic progenitor cells
por: Stavrou, Eleana F., et al.
Publicado: (2017)

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display
por: Chen, Chuan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_00aemtaopoahj63pi535crh33g