Endoplasmic reticulum stress enhances fibrosis through IRE1α‐mediated degradation of miR‐150 and XBP‐1 splicing

ER stress results in activation of the unfolded protein response and has been implicated in the development of fibrotic diseases. In this study, we show that inhibition of the ER stress‐induced IRE1α signaling pathway, using the inhibitor 4μ8C, blocks TGFβ‐induced activation of myofibroblasts in vit...

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Detalles Bibliográficos
Autores principales: Heindryckx, Femke, Binet, François, Ponticos, Markella, Rombouts, Krista, Lau, Joey, Kreuger, Johan, Gerwins, Pär
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931288/
https://www.ncbi.nlm.nih.gov/pubmed/27226027
http://dx.doi.org/10.15252/emmm.201505925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931288/
https://www.ncbi.nlm.nih.gov/pubmed/27226027
http://dx.doi.org/10.15252/emmm.201505925

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