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Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women

Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffe...

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Autores principales: Lee, A H, Tan, L 'B, Hiramatsu, N, Ishisaka, A, Alfonso, H, Tanaka, A, Uemura, N, Fujiwara, Y, Takechi, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931312/
https://www.ncbi.nlm.nih.gov/pubmed/27270110
http://dx.doi.org/10.1038/nutd.2016.19
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author Lee, A H
Tan, L 'B
Hiramatsu, N
Ishisaka, A
Alfonso, H
Tanaka, A
Uemura, N
Fujiwara, Y
Takechi, R
author_facet Lee, A H
Tan, L 'B
Hiramatsu, N
Ishisaka, A
Alfonso, H
Tanaka, A
Uemura, N
Fujiwara, Y
Takechi, R
author_sort Lee, A H
collection PubMed
description Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38–73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have anti-diabetic effects but further replications with large samples of both genders are recommended.
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spelling pubmed-49313122016-07-14 Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women Lee, A H Tan, L 'B Hiramatsu, N Ishisaka, A Alfonso, H Tanaka, A Uemura, N Fujiwara, Y Takechi, R Nutr Diabetes Short Communication Coffee consumption has been reported to reduce the risk of type 2 diabetes in experimental and epidemiological studies. This anti-diabetic effect of coffee may be attributed to its high content in polyphenols especially caffeic acid and chlorogenic acid. However, the association between plasma coffee polyphenols and diabetic risks has never been investigated in the literature. In this study, fasting plasma samples were collected from 57 generally healthy females aged 38–73 (mean 52, s.d. 8) years recruited in Himeji, Japan. The concentrations of plasma coffee polyphenols were determined by liquid chromatography coupled with mass tandem spectrometer. Diabetes biomarkers in the plasma/serum samples were analysed by a commercial diagnostic laboratory. Statistical associations were assessed using Spearman's correlation coefficients. The results showed that plasma chlorogenic acid exhibited negative associations with fasting blood glucose, glycated hemoglobin and C-reactive protein, whereas plasma total coffee polyphenol and plasma caffeic acid were weakly associated with these biomarkers. Our preliminary data support previous findings that coffee polyphenols have anti-diabetic effects but further replications with large samples of both genders are recommended. Nature Publishing Group 2016-06 2016-06-06 /pmc/articles/PMC4931312/ /pubmed/27270110 http://dx.doi.org/10.1038/nutd.2016.19 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Short Communication
Lee, A H
Tan, L 'B
Hiramatsu, N
Ishisaka, A
Alfonso, H
Tanaka, A
Uemura, N
Fujiwara, Y
Takechi, R
Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title_full Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title_fullStr Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title_full_unstemmed Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title_short Plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy Japanese women
title_sort plasma concentrations of coffee polyphenols and plasma biomarkers of diabetes risk in healthy japanese women
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931312/
https://www.ncbi.nlm.nih.gov/pubmed/27270110
http://dx.doi.org/10.1038/nutd.2016.19
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