Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia

Besides the conventional carbon sources, acetyl-CoA has recently been shown to be generated from acetate in various types of cancers, where it promotes lipid synthesis and tumour growth. The underlying mechanism, however, remains largely unknown. We find that acetate induces a hyperacetylated state...

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Detalles Bibliográficos
Autores principales: Gao, Xue, Lin, Shu-Hai, Ren, Feng, Li, Jin-Tao, Chen, Jia-Jia, Yao, Chuan-Bo, Yang, Hong-Bin, Jiang, Shu-Xia, Yan, Guo-Quan, Wang, Di, Wang, Yi, Liu, Ying, Cai, Zongwei, Xu, Ying-Ying, Chen, Jing, Yu, Wenqiang, Yang, Peng-Yuan, Lei, Qun-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931325/
https://www.ncbi.nlm.nih.gov/pubmed/27357947
http://dx.doi.org/10.1038/ncomms11960

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931325/
https://www.ncbi.nlm.nih.gov/pubmed/27357947
http://dx.doi.org/10.1038/ncomms11960

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