Programmed activation of cancer cell apoptosis: A tumor-targeted phototherapeutic topoisomerase I inhibitor

We report here a tumor-targeting masked phototherapeutic agent 1 (PT-1). This system contains SN-38—a prodrug of the topoisomerase I inhibitor irinotecan. Topoisomerase I is a vital enzyme that controls DNA topology during replication, transcription, and recombination. An elevated level of topoisome...

Descripción completa

Detalles Bibliográficos
Autores principales: Shin, Weon Sup, Han, Jiyou, Kumar, Rajesh, Lee, Gyung Gyu, Sessler, Jonathan L., Kim, Jong-Hoon, Kim, Jong Seung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931442/
https://www.ncbi.nlm.nih.gov/pubmed/27374023
http://dx.doi.org/10.1038/srep29018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4931442/
https://www.ncbi.nlm.nih.gov/pubmed/27374023
http://dx.doi.org/10.1038/srep29018

Ejemplares similares